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Sponsored Clinical Research Published in Peer-Reviewed Scientific Journals and Presented at Scientific Conferences

Calendar Year 2010

Publications

Jin Y, Cui X, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ.  Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate. Mol Nutr Food Res. 54:1-9, 2010.

Roll S, Nocon M. Willich SN.  Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: a randomized, double-blind, placebo-controlled trial.  Br J Nutr. 23:1-5, 2010.

Goldfarb AH, Garten RS, Cho C, Chee PD, Chambers LA.  Effects of a fruit/berry/vegetable supplement on muscle function and oxidative stress. Med Sci Sports Exerc. 2010 Aug 2. [Epub ahead of print].

Walter AA, Smith AE, Kendall KL, Stout JR, Cramer JT. Six weeks of high-intensity interval training with and without beta-alanine supplementation for improving cardiovascular fitness in women. J Strength Cond Res. 24:1199-207, 2010.

Sale C, Saunders B, Harris RC.  Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance. Amino Acids. 39:321-33, 2010.

Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr.  Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. 42:1162-73, 2010.

Baguet A, Bourgois J, Vanhee L, Achten E, Derave W.  Important role of muscle carnosine in rowing performance.  J Appl Physiol. 2010 Jul 29. [Epub ahead of print].

Baguet A, Koppo K, Pottier A, Derave W.  Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise.  Eur J Appl Physiol.
108:495-503, 2010.

Presentations

Harris RC, Kim HJ, Kim CK, Kendrick IP, Price KA, Wise JA.  Simultaneous changes in muscle carnosine and taurine during and following supplementation with β-alanine.  Medicine and Science in Sports and Exercise, Baltimore MD, June 2010.

Sale C, Saunders B, Hudson S, Sunderland CD, Wise JA, Harris RC.  Effect of β-alanine supplementation, with and without sodium bicarbonate, on high-intensity cycling capacity.  Medicine and Science in Sports and Exercise, Baltimore MD, June 2010.

Stellingwerff T, Anwander H, Effer A, Buehler T, Kreis R, Boesch C, Decombaz J.  The effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout.  Medicine and Science in Sports and Exercise, Baltimore MD, June 2010.

Roll S, Nocon M, Willich SN.  Attenuation of common cold symptoms by encapsulated juice powder concentrate.  Experimental Biology, Anaheim CA, 2010.

Chapple ILC, Milward MM, Ling-Mountford N, Weston P, Dallal GE, Matthews JB.  Adjunctive effects of a dietary supplement comprising dried whole fruit, vegetable and berry juice concentrates on clinical outcomes of treatment of periodontitis.  Experimental Biology, Anaheim CA, 2010.

Bamonti F, Novembrino C, Vigna L, DeGiuseppe R, DeLiso F, Pellegatta M, Gregori D, Noce CD, Accinni R.  Significant decrease in homocysteine and ox-LDL in healthy heavy smokers after nutraceutical supplementation.  Experimental Biology, Anaheim CA, 2010.

Bamonti F, Pellegatta M, Novembrino C, DeGiuseppe R, DeLiso F, Gregori D, Vigna L.  Effecs of nutraceutical supplementation on respiratory function in healthy heavy smokers.  Experimental Biology, Anaheim CA, 2010.

Esfahani A, Truan J, Srichaikul K. Kendall CWC.  The effect of mixed fruit and vegetable concentrates on biomarkers of cardiovascular disease: a review of the clinical evidence.  Experimental Biology, Anaheim CA, 2010.

Calendar Year 2009

Publications

Wise JA, Kaats GR, Preuss HG, Morin RJ.  β-Carotene and α-tocopherol in healthy overweight adults; depletion kinetics are correlated with adiposity.  Intl J Food Sci Nutr. 60:65-75, 2009.

Kendrick IP, Kim HJ, Harris RC, Kim CK, Dang VH, Lam TQ, Bui TT, Wise JA. The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres.  Eur J Appl Physiol. 106:131-8, 2009.

Van Thienen R, Van Proeyen K, Vanden Eynde B, Puype J, Lefere T, Hespel P. Beta-alanine improves sprint performance in endurance cycling.  Med Sci Sports Exerc. 41:898-903, 2009.

Baguet A, Reyngoudt H, Pottier A, Everaert I, Callens S, Achten E, Derave W.  Carnosine loading and washout in human skeletal muscles.  J Appl Physiol. 106:837-42, 2009.

Smith AE, Moon JR, Kendall KL, Graef JL, Lockwood CM, Walter AA, Beck TW, Cramer JT, Stout JR.  The effects of beta-alanine supplementation and high-intensity interval training on neuromuscular fatigue and muscle function. Eur J Appl Physiol. 105:357-63, 2009.

Lamprecht M, Oettl K, Schwaberger G, Hofmann P, Greilberger J.  Protein modification responds to exercise intensity and antioxidant supplementation. Medicine & Science in Sports & Exercise.  41:155-163, 2009.

Presentations

Harris RC, Jones GA, Kim HJ, Kim CK, Price KA, Wise JA.  Changes in muscle carnosine of subjects with 4 weeks supplementation with a controlled release formulation of beta-alanine (Carnosyn®), and for 6 weeks post.  Experimental Biology, New Orleans. April 2009.

Calendar Year 2008

Publications

Hoffman JR, Ratamess NA, Faigenbaum AD, Ross R, Kang J, Stout JR, Wise JA. Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players.  Nutr Res. 28:31-5, 2008.

Hoffman, J. Ratamess NA, Ross R, Kang J, Magrelli J, Neese K, Faigenbaum AD, Wise JA. 
β-alanine and the hormonal response to exercise.  Int J Sports Med. 29:952-958, 2008

Kendrick IP, Harris RC, Kim HJ, Kim CK, Dang VH, Lam TQ, Bui TT, Smith M, Wise JA.  The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition.  Amino Acids. 34:547-54, 2008.

Stout JR, Graves BS, Smith AE, Hartman MJ, Cramer JT, Beck TW, Harris RC. The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind rancomized study. J of the International Society of Sports Nutrition. 7:21-26, 2008.

Mahmoud FF, Abul HT, Haines DD, Omu AE, Diejomaoh M. Wise JA, Abu Donia MB. Butyrylcholinesterase activity and lymphocyte subpopulations in peripheral blood of Kuwaiti women experiencing recurrent spontaneous abortion.  J Reprod Immunol. 77:186-94, 2008.

Presentations

Harris RC, Jones G, Wise JA.  The plasma concentration-time profile of beta-alanine using a controlled-release formulation (Carnosyn®).  Experimental Biology, San Diego, April 2008.

Harris RC, Kim HJ, Jones G, Lee JS, Kim CK, Wise JA.  The muscle carnosine and taurine content of elderly non-obese Korean males with impaired glucose tolerance.  Experimental Biology, San Diego, April 2008.

Calendar Year 2007

Publications

Derave W, Pothier A, Reyngoudt H, Ozdemir M, Koppo K, Harris RC, Wise JA, Achten E.       β-alanine supplementation augments muscle carnosine content and attenuates fatigue in trained athletes.  J. Applied Physiology (Aug 9, 2007) doi:10.1152/japlphysiol 100397, 2007.

Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA. Influence of    β-alanine supplementation on skeletal muscle canosine concentrations and high intensity cycling capacity.  Amino Acids. 32: 225-233, 2007.

Ozdemir MS, Reyngoudt H, De Deene Y, Sazak HS, Fieremans E, Delputte S, D’Asseier Y, Derave W, Lemahieu I, Achten E.  Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy.  Phys Med Biol. 52:6781-6794, 2007.

Kawashima A, Madarame T, Koike H, Komatsu Y, Wise JA.  Four week supplementation with mixed fruit and vegetable concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine. Asia Pacific J Clinical Nutrition. 16:411-421, 2007.

Kraemer WJ, Vingren JL, Silvestre R, Spiering BA, Halfield DL, Fragala MS, Maresh CM, Volek JS.  Effect of adding exercise to a diet containing glucomannan.  Metabolism 56:1149-1158, 2007.

Lamprecht M, Oettl K, Schwaberger G, Hofmann P, Greilberger JF.  Several indicators of oxidative stress, immunity and illness improved in trained men consuming an encapsulated juice powder concentrate for 28 weeks.  Journal of Nutrition 137:2737-2741, 2007.

Arifhodzic NA, Mahmoud FF, Abul HT, Haines DD, Al-Dowessan AR, Ammar IM,     Novotney L, Wise JA.  Major lymphocyte populations and T Cell expression of ICAM-1        and L-selectin adhesion molecules, in Kuwaitis with asthma and rhinitis.  Archives of Environmental and Occupational Health. 60:243-247, 2007.

Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Harris RC.  Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.    Amino Acids 32:381-386, 2007.

Tallon MJ,  Harris RC, Maffulli N, Tarnopolsky M. Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects. Biogerontology 8:129-137, 2007.

Houston MC, Cooil B, Olaffson BJ, Raggi P.  Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects:      a pilot study. Evidence – based Complementary and Alternative Medicine. 4:1-8, 2007.

Zoeller RF, Stout JR, O’Kroy J, Torok D, Mielke M.  Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion.  Amino Acids 33:505-510, 2007.

Presentations

Derave W, Pothier A, Reyngoudt H, Ozdemir M, Koppo K, Harris RC, Wise JA, Achten E.       β-alanine supplementation augments muscle carnosine content and attenuates fatigue in trained athletes. National Strength and Conditioning Association Annual Conference, Atlanta, July 2007.

Harris RC.  Regulation of muscle carnosine by diet, supplementation and training: Implications for performance.  International Society of Sport Nutrition, Las Vegas NV, June 2007.

Harris RC, Kendrick IP, Kim C, Kim H, Dang VH, Lam TQ, Bui TT, Wise JA. The effect of physical training on the carnosine content of V lateralis using a one-leg training model.      Medicine and Science in Sports and Exercise, 39(5) S91, June 2007.

Kim C, Kim H, Lee YW, Harris RC, Sale C, Harris DB, Wise JA.  The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training.  Medicine and Science in Sports and Exercise, 39 (5) S364, June 2007.

Stout JR, Cramer JT, Zoeller RF, Torok DJ.  Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.  Medicine and Science in Sports and Exercise, 39 (5) S365, June 2007.

Ho JY, Kraemer WJ, FACSM, Vingren JL, Silvestre R, Hatfield DL, Spiering BA, Fragala MS, Puglisi MJ, Quann EE, Forsythe CE, Yamamoto LM, Anderson JM, Volek JS, Maresh CM.  Effect of adding exercise to a diet containing glucomannan in men.  Medicine and Science in Sports and Exercise, 39 (5), June 2007.

Harris RC, Edge J, Kendrick IP, Bishop D, Goodman C, Wise JA.  The effect of very high interval training on the carnosine content and buffering capacity of V lateralis from humans.     Experimental Biology, Washington D.C., April 2007.

Harris RC, Jones G, Hill CA, Kendrick IP, Kim C, Kim H, Dang VH, Edge J, Wise JA.                     The carnosine content of V lateralis in vegetarians and omnivores.  Experimental Biology, Washington D.C., April 2007.

Harris RC, Kendrick IP, Kim C, Kim H, Dang VH, Lam TQ, Bui TT, Wise JA. The effect of whole body physical training on the carnosine content of V lateralis. Experimental Biology, Washington D.C., April 2007.

Tallon MJ, Harris RC, Child R. Acute changes in plasma carnosine, creatine and markers of purine degradation following exercise. Experimental Biology, Washington D.C., April 2007.

Tallon MJ, Harris RC, Kim HJ, Kim CK.  Single muscle fibre analysis of carnosine and associated metabolites in Korean breath hold divers (AMA). Experimental Biology, Washington D.C., April 2007.

Wise JA, Harris RC, Hill CA.  Comparative and evolutionary adaptation of muscle buffering capacity in species subject to varying degrees of acidosis. Experimental Biology, Washington D.C., April 2007.

Vingren JL, Silvestre R, Hatfield DL, Spiering BA, Fragala MS, Ho JY, Maresh CM, Volek JS, Defreitas JM, Puglisi MJ, Forsythe CE, Quann EE, Anderson JM, Kraemer WJ.  Effects of adding exercise to a  diet containing glucomannan. Experimental Biology, Washington D.C., April 2007.

Bamonti F, Novembrino C, Accinni R, Della Noce C, Gregori D, Lonati S, Schiraldi G.  The effects of nutrition supplements in heavy smokers.  Experimental Biology, Washington D.C., April 2007.

 Hill CA, Harris RC, Boobis LH, Sale C, Wise JA. Effect of 4 weeks β-alanine supplementation upon sprint and sustained high intensity cycling. British Association of Sport and Exercise Science, Student Conference, University of Chichester, April, 2007.

Jones GA, Harris RC, Kendrick IP, CK, Kim HJ, Dang VH, Edge J. Comparison of the carnosine content of V Lateralis of vegetarians and omnivores. British Association of Sport and Exercise Science, Student Conference, University of Chichester, April, 2007.

Calendar Year 2006

Publications

Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA.  The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis.  Amino Acids. 30:279-289, 2006.

Bamonti F, Novembrino C, Ippolito S, Soresi E, Ciani A, Lonati S, Scurati-Manzoni E, Cighetti G.  Increased free malondialdehyde concentrations in smokers normalise with a mixed fruit and vegetable juice concentrate: a pilot study.  Clin Chem Lab Med 44:391-395, 2006.

Bloomer RJ, Goldfarb AH, McKenzie MJ.  Oxidative stress response to aerobic exercise: comparison of antioxidant supplements.  Medicine and Science in Sports and Exercise.            38: 1098-1105, 2006.

Nance MP, Rowe CA, Nieves C, Percival SS.  Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate.     Journal of Nutrition, 136: 2606-2610, 2006.

McCarty M. cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes.  Medical Hypotheses 66: 323-328, 2006.

McCarty M.  Induction of heat shock proteins may combat insulin resistance.  Medical Hypotheses 66: 527-534, 2006.

McCarty M.  PKC-mediated modulation of L-type calcium channels may contribute to fat-induced insulin resistance.  Medical Hypotheses 66: 824-831, 2006.

McCarty M.  Isoflavones made simple–Genistein’s agonist activity for the beta-type estrogen receptor mediates their health benefits.  Medical Hypotheses 66: 1093-1114, 2006.

McCarty M.  Rationale for a novel nutraceutical complex ‘K-water’: Potassium taurine bicarbonate (PTB).  Medical Hypotheses 67: 65-70, 2006.

McCarty M. Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders.  Medical Hypotheses 67: 251-269, 2006.

Hoffman JR, Ratamess NA, Kang J, Mangine G, Faigenbaum AD, Stout JR. Effect of creatine and β-alanine supplementation on performance and endocrine responses in strength/power athletes.  International Journal of Sports Nutrition and Exercise Metabolism, 16:430-446, 2006.

Stout JR, O’Kroy J, Mielke M, Zoeller R, Torok D, Cramer JT, Rakes M, Graves BS.  Effects of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold.  Journal of Strength & Conditioning Research, 20:928-931, 2006.

Presentations

Dang VH, Kendrick IP, Kim CK, Harris RC, Kim HJ, Lam TQ, Bui TT, Wise JA. The effect of β-alanine (Carnosyn™) supplementation on muscle carnosine synthesis during a 10 week program of strength training. 13th International Conference Biochemistry of Exercise, Seoul, Korea, October 2006.

Harris RC, Ponte J, Hill CA, Sale CA, Jones GA, Kim HJ, Wise JA.  Effect of 14 and 28 days β-alanine (Carnosyn®) supplementation on isometric endurance of the knee extensors.  13th International Conference Biochemistry of Exercise, Seoul, Korea, October 2006.

Kendrick IP, Harris RC, Kim CK, Kim HJ, Dang VH, Lam TQ, Bui T, Wise JA. The effect of
β-alanine (Carnosyn®) supplementation on muscle carnosine synthesis during 4 weeks using a one-leg training model.  13th International Conference Biochemistry of Exercise, Seoul, Korea, October 2006.

Kim HJ, Kim CK, Lee YW, Harris RC, Sale C, Harris DB, Wise JA. The effect of a supplement containing β-alanine on muscle carnosine synthesis and exercise capacity, during 12 weeks combined endurance and weight training. 13th International Conference Biochemistry of Exercise, Seoul, Korea, October 2006.

Harris RC, Kim CK, Kim HJ, Sale C, Wise JA.  The effect of a supplement containing
β-alanine on muscle carnosine synthesis and exercise capacity, during 12 week combined endurance and weight training.  International Society of Sports Nutrition, Las Vegas NV, June 2006.

Harris RC, Ponte J, Hill CA, Sale CA, Jones GA, Kim HJ, Wise JA.  Effect of 14 and 28 days
β-alanine (Carnosyn®) supplementation on isometric endurance of the knee extensors.  International Society of Sports Nutrition, Las Vegas NV, June 2006.

Kendrick IP, Harris RC, Kim CK, Kim HJ, Dang VH, Lam TQ, Bui TT, Wise JA.  The effect of β-alanine (CarnoSyn®) supplementation on muscle carnosine synthesis during 4 weeks using a one-leg training model. International Society of Sports Nutrition, Las Vegas NV, June 2006.

Kendrick IP, Harris RC, Kim CK, Kim HJ, Dang VH, Lam TQ, Bui TT, Wise JA. The effect of β-alanine (Carnosyn®) supplementation on muscle carnosine synthesis during a 10 week program of strength training.  International Society of Sports Nutrition Conference, Las Vegas, June 2006.

Kim HJ,  Kim CK, Lee YW, Harris RC, Sale C, Harris DB, Wise JA.  The effect of a supplement containing β-alanine on muscle carnosine synthesis and exercise capacity, during 12 wk combined endurance and weight training.  International Society of Sports Nutrition, Las Vegas NV, June 2006.

Harris RC, Hill CA, Sale C, Jones GA, Kim HJ, Wise JA.  Effects of 14 days of beta-alanine supplementation on isometric endurance of the knee extensors. Medicine and Science in Sports and Exercise, 38(5) S125, June 2006.

Harris R, Kim CH, Kim HJ, Sale C, Wise JA.  The effect of a β-alanine supplement on the muscle carnosine content during training.  Experimental Biology, San Francisco, April 2006.

Harris RC, Kim HJ, Kim CK, Lee YW, Sale C, Harris DB, Wise JA.  The effect of a supplement containing β-alanine on muscle carnosine synthesis and exercise capacity, during 12 wk combined endurance and weight training. J Sport Sci: 25; 336-337, 2006.

Kendrick IP, Harris RC, Kim CK, Kim HJ, Dang VH, Lam TQ, Bui TT, Wise JA. The effect of β-alanine supplementation on muscle carnosine synthesis during 4 wks using a one-leg training model. J Sport Sci: 25; 339, 2006.

Kendrick IP, Kim CK, Viet DH, Harris RC, Kim HJ, Lam TQ, Bui TT, Wise JA. The effect of β-alanine supplementation on muscle carnosine during a 10 weeks strength training. J Sport Sci: 25; 339-340, 2006.

Wise JA, Kawashima A, Komatsu Y.  Four week supplementation with mixed fruit and vegetable concentrates elevated protective serum antioxidants and folate and decreased plasma homocysteine. Experimental Biology, San Francisco, April 2006.

Nantz MP, Rowe CA, Nieves C, Percival SS.  Immunity and antioxidant capacity in humans is enhanced by consumption of a fruit and vegetable juice concentrate.  Experimental Biology, San Francisco, April 2006.

Harris RC, Kim CK, Dang VH.  The effect of dietary supplementation and training on carnosine synthesis in muscle; implications to pH buffering and exercise performance. 5th Open Sports Scientific Conference, University of Physical Education & Sports II, Ho Chi Minh City, Vietnam, April 2006.

Mahmoud FF, Arifhodzic NA, Abul HT, Haines DD, Wise JA.  Cetirizine modulates lymphocyte activation in patients with allergic rhinitis and asthma. 7th International Conference on New Trends in Immunosuppression and Immunotherapy, Berlin, February 2006.

Calendar Year 2005

Publications

Tallon MJ, Harris RC, Boobis L, Fallowfield J, Wise JA.  The carnosine content of vastus lateralis is elevated in resistance trained bodybuilders.  Journal of Strength & Conditioning Research 19:725-729, 2005.

Kritchevsky D, Tepper SA.  Influence of a fiber mixture on serum and liver lipids and on fecal fat excretion in rats.  Nutrition Research 25: 485-489, 2005.

Arifhodzic NA, Mahmoud FF, Abul HT, Haines DD, Al-Dowaisan AR, Ammar IM, Novotny L, Wise JA.  Major lymphocyte populations and T-cell expression of ICAM-1 and L-selectin adhesion molecules in Kuwaitis with asthma and rhinitis. Arch Environ Occup Health. 60:243-7, 2005.

Presentations

Kawashima A, Madarame T, Koike H, Komatsu Y, Wise JA.  Protective serum antioxidants and folate are elevated and plasma homocysteine is reduced after supplementation with mixed fruit and vegetable concentrates.  International Interdisciplinary Conference on Vitamins, Enzymes and Biofactors.  Awaji, Hyogo, Japan, November 2005.

Harris RC, Hill CA, Sale C, Boobis L, Kim HJ, Harris DB, Wise JA.  The effect of 4 to 10w dietary supplementation with beta-alanine (free or peptide bound form) on the carnosine content of muscle, and types I and II muscle fibres.  J Sport Sci: Annual Conference of the British Association of Sport and Exercise Sciences Loughborough, 4-7 September 2005: 23.

Harris RC, Hill CA, Harris DB, Sale C, Tallon MJ, Boobis L, Kim HK, Kim CK, Cho J, Wise JA.  The influence of β-alanine supplementation and training on the muscle carnosine content in human v lateralis, and the effect of this on exercise performance.  9th International Congress on Amino Acids & Proteins, Vienna, August 2005. [Amino Acids 29:12, 2005]

Harris RC, Kim HJ, Harris DB, Hill CA, Kim CK, Boobis L, Sale C, Wise JA. The distribution of carnosine and taurine in different muscle fibre types from human v lateralis and the effects of beta-alanine supplementation.  9th International Congress on Amino Acids & Proteins, Vienna, August 2005. [Amino Acids 29:13, 2005]

Cramer JT, Stout JR, Culbertson JY, Egan AD.  Effects of short-term isokinetic resistance training on peak torque, acceleration time, electromyography, and mechanomyography of the vastus lateralis during eight days of supplementation with beta-alanine and creatine.  International Society of Sports Nutrition, New Orleans, June 2005.

Harris RC.  Muscle carnosine elevation with supplementation and training, and the effects of elevation on exercise performance.  International Society of Sports Nutrition, New Orleans, June 2005.

Rakes M. Zoeller R, O’Kroy JA, Torok D, Stout JR, Mielke M, Graves BS. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on oxygen uptake, ventilatory and lactate thresholds, and time to exhaustion. International Society of Sports Nutrition, New Orleans, June 2005.

Stout JR, O’Kroy J, Mielke M, Zoeller R, Torok D, Cramer JT, Rakes M, Graves BS.  Effects of 28 days of beta-alanine and creatine monohydrate supplementation on physical working capacity at neuromuscular fatigue threshold.  International Society of Sports Nutrition, New Orleans, June 2005.

Hill CA, Harris RC, Kim HJ, Boobis L, Sale C, Wise JA.  The effect of β-alanine and creatine monohydrate supplementation on muscle composition and exercise performance. Medicine & Science in Sports and Exercise, 37(5) S348, June 2005.

Kim HJ, Cho J. Kim CK, Harris RC, Harris RC, Sale C, Wise JA.  Effect of 12 days training of Korean speed skaters on muscle fibre morphology and carnosine content.  Medicine & Science in Sports and Exercise, 37(5) S192, June 2005.

Goldfarb A, McKenzie MJ, Bloomer, RJ.  Oxidative Stress Response to Aerobic Exercise: Comparison of Antioxidant and Phytonutrient Supplementation. Medicine & Science in Sports & Exercise, 37(5) Supplement: S349, June 2005.

McKenzie MJ, Goldfarb AH, Bloomer RJ, Kuman M.  Gender Comparison of Oxidative Stress Markers with Antioxidant and Phytonutrient Supplementation: Rest and Exercise. Medicine & Science in Sports & Exercise, 37(5) Supplement: S46, June 2005.

Houston M.  Efficacy of a Phytonutrient Nutritional Concentrate Powder on Systolic and Diastolic Blood Pressure and Arterial Compliance. American Society of Hypertension, San Francisco, May 2005.

Houston M.  Efficacy of a Phytonutrient Nutritional Concentrate Powder on Coronary Artery Calcification and Calcium Score (CS) Assessed by Electron Beam Tomography (EBT).  American Society of Hypertension, San Francisco, May 2005.

Harris RC, Harris DB, Kim HJ, Hill CA, Boobis L, Sale C, Wise JA.  The distribution of carnosine in different muscle fibre types with beta-alanine supplementation.  Experimental Biology, San Diego CA, April 2005.

Harris RC, Hill CA, Kim HJ, Boobis L, Sale C, Harris DB, Wise JA. Beta-alanine supplementation for 10 weeks significantly increased muscle carnosine levels.  Experimental Biology, San Diego CA, April 2005.

Tallon MJ, Harris RC, Boobis L, Almada A, Wise JA, Murray D.  The effect of L-carnosine supplementation on its content in muscle and types I & II muscle fibres.  Experimental Biology, San Diego CA, April 2005.

Nantz MP, Rowe CA, Nieves CJ, Lee JH, Talcott ST, Percival SS. Immunomodulating activity of a fruit and vegetable juice concentrate in human subjects. Experimental Biology, San Diego, 2005.

Goldfarb, AH, McKenzie MJ, Bloomer RJ, Kumar M.  Nutritional intake influence on exercised-induced oxidative stress to two supplements. Experimental Biology, San Diego, 2005.

Calendar Year 2004

Publications

Kiefer I, Prock P, Lawrence C, Wise J, Bieger W, Bayer P, Rathmanner T, Kunze M, Rieder A.  Supplementation with mixed fruit and vegetable juice concentrates increased serum antioxidants and folate in healthy adults. Journal of the American College of Nutrition 23: 205-211, 2004.

Mahmoud FF, Haines DD, Abul HT, Abal AT, Onadeko BO, Wise JA.  In vitro effects of astaxanthin combined with ginkgolide B on T lymphocyte activation in peripheral blood mononuclear cells from asthmatic subjects.  Journal of Pharmacological Science 94:129-136, 2004.

Mahmoud FF, Abul HT, Haines DD, Azeamuzi CI, Abal AT, Wise JA.  In vitro suppression of lymphocyte activation by citirazene and azelastine.  International Journal of  Immunopharmacology, In press.

Mahmoud F, Al-Dowaisan A, Haines D, Azeamuzi C, Abul H, Khadadah M, Wise J.  In vitro suppression of lymphocyte activation by citirazene or azelastine in combination with ginkgolide B or astaxanthin.  International Journal of Immunopharmacology, In press.

Haines DD, Wise JA, Ferdinandy P, Tosaki A.  Astaxanthin interacts with ginkgo biloba extract (EGB761) and vitamin C to suppress asthma-associated inflammation in histamine-challenged rats.  International Journal of Immunopharmacology, In press.

Presentations

Mahmoud FF, Al-Dowaisan AA, Haines DD, Abul HT, Azeamuzi CI, Wise JA.   In vitro suppression of lymphocyte activation by citirazene or azelastine in combination with ginkgolide B or astaxanthin.  New Trends in Immunosuppression, Salzburg, Austria, February 2004.

Haines DD, Wise JA, Ferdinandy P, Mahmoud FF, Tosaki A.  Astaxanthin interacts with ginkgo biloba extract (EGB761) and vitamin C to suppress asthma-associated inflammation in histamine-challenged guinea pigs: a comparison with ibuprofen. New Trends in Immunosuppression, Salzburg, Austria, February 2004.

Wise JA, Kaats G, Preuss H, Morin RJ.  Four-week supplementation with mixed fruit and vegetable juice concentrates increased serum tocopherol and carotenoids; levels remained elevated up to 4 weeks after supplement cessation.  Experimental Biology, Washington DC, April 2004.

Wise JA.  Results of a randomized, double blind, placebo-controlled clinical study: supplementation with mixed fruit and vegetable juice concentrates increases serum antioxidants associated with reduced risk of cardiovascular disease.  Nutraceutical and Medicine Conference, American Nutraceutical Association, Phoenix, AZ, April 2004.

Wise JA.  The protective role of phytonutrients against cancer.  32nd Annual Cancer Convention, Cancer Control Society, Universal City, CA, September 2004.

Hill CA, Harris RC, Kelly J, Fallowfield JL.  The effect of four weeks Beta-alanine supplementation on the performance of a repeated sprints exercise protocol.  European College Sport Science Conference, Clairmont-Ferrand, France, 2004.

Calendar Year 2003

Publications

Plotnick GD, Corretti MC, Hesslink RL, Vogel RA, Wise, JA.  Effect of supplemental phytonutrients on impairment of flow mediated brachial artery vasoactivity following a single high-fat meal.  Journal of the American College of Cardiology, 41:1744-1749, 2003.

Samman S, Sivarajah G, Man JC, Ahmad ZI, Petocz P, Caterson I.  A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers homocysteine concentration in men.  Journal of Nutrition, 133: 2188-2193, 2003.

Panunzio MF, Pisano A, Antoniciello A, Di Martino V, Frisoli L, Cipriani V, Mongelli MA, Bronzetti G.  Supplementation with fruit and vegetable concentrate decreases plasma homocysteine levels in a dietary controlled trial.  Nutrition Research, 23: 1221-1228, 2003.

Haines D, Mahmoud F, Wise JA. Clinical biochemical and pharmacological properties of Gingko biloba: potential for use in adjunct therapies. (Review) Submitted 2003.

Kiefer I, Prock P, Lawrence C, Rathmanner T, Kunze M, Rieder A. Effect of phytonutrient supplementation on well-being and mood.  Submitted 2003.

Presentations

Harris RC, Hill CA, Wise JA, Kramer WJ.  The effect of combined beta-alanine and creatine monohydrate supplementation on exercise performance. Medicine and Science in Sports and Exercise, 35(5) S218, May 2003.

Tallon MJ, Harris RC, Maffulli N, Tarnopolsky M.  In vivo sarcopenic related changes of carnosine in human skeletal muscle fibres.  Medicine and Science in Sports and Exercise, 35(5) S96, May 2003.

Harris RC, Boobis L, Hill C, Tallon MJ, Hesslink RL, Wise JA.  Elevation of carnosine in muscle of normal subjects by supplementation with β-alanine in free or peptide bound form.  Experimental Biology, San Diego, April 2003.

Harris RC, Dunnett M, Fallowfield J, Hesslink RL, Wise JA.  Changes in plasma β-alanine concentration following administration of free or peptide bound forms.   Experimental Biology, San Diego, April 2003.

Harris RC, Dunnett D. Fallowfield J, Wise JA.  Change in plasma beta-alanine concentration following administration of free or peptide bound form.  Experimental Biology, San Diego, April 2003.

Harris RC, Hill CA, Boobis L, Tallon MJ, Wise JA.  Elevation of muscle carnosine content with administration of beta-alanine in the free or peptide bound form.  Experimental Biology, San Diego, April 2003.

Hill CA, Harris RC, Tallon MJ, Boobis L, Fallowfield J, Wise JA.  Comparison of the effect of 4 weeks supplementation with beta-alanine or carnosine on the carnosine content of skeletal muscle.  British Association of Sports & Exercise Sciences (BASES), Coventry, 2003.

Calendar Year 2002

Publications

Mahmoud FF, Abul HT, Haines DD, Abul AT, Wise JA.  In vitro effects of Ginkgolide B combined with cyclosporin A on T lymphocyte activation and IL-5 expression in peripheral blood mononuclear cells from asthmatic subjects. Transplantation Proceedings, 34:2958-2961, 2002.

Volek JS, Gomez AL, Love DM, Davis CJ, Weyers AM, Hesslink Jr RL, Wise JA, Kraemer WJ. Effects of an 8-week weight loss program on cardiovascular disease risk factors and regional body composition.  European Journal of Clinical Nutrition, 56: 585-592, 2002.

Gallaher DD, Gallaher CM, Mahrt GJ, Carr TP, Hollingshead C, Hesslink Jr RL, Wise JA. A glucomannan and chitosan fiber supplement decreases plasma cholesterol and increases cholesterol excretion in overweight normocholesterolemic humans. Journal of the American College of Nutrition, 21: 428-433, 2002.

Harris RD, Nevill M, Harris DB, Fallowfield JL, Bogdanis GC, Wise J. Absorption of creatine supplied as a drink, in meat or in solid form. Journal of Sports Science, 20: 147-151, 2002.

Presentations

Wise, JA.  Protective Serum Antioxidants are Elevated after Supplementation with Mixed Fruit and Vegetable Concentrates.  Experimental Biology, New Orleans, April 2002.

Samman S, Sivarajah G, Man J. Ahmad Z, Petocz P, Caterson I. Supplementation with a mixed fruit and vegetable concentrate increases plasma antioxidant vitamin and lowers plasma homocysteine in men.  Experimental Biology, New Orleans, April 2002.

Mahmoud FF, Abul HT, Haines DD, Abul AT, Wise JA.  In vitro effects of Ginkgolide B combined with Cyclosporin A on T lymphocyte activation and IL-5 expression in peripheral blood mononuclear cells from asthmatic subjects.  5th International Conference on New Trends in Immunosuppression, Geneva, Switzerland, February 7-10 2002.


Calendar Year 2001

Presentations

Plotnick GD, Wise JA, Vogel R.  The Effects of Dietary Supplements on Endothelial Function:  Results of a Recent Study Evaluating the Effect of a Phytonutrient Product on Brachial Artery Flow Mediated Vasoactivity.  American Nutriceutical Association Conference on Nutraceuticals and Medicine, Nashville, TN, October 2001.

Kiefer I, Prock P, Lawrence C, Bayer P, Kunze M, Rieder A.  Gender specific differences in dietary habits and changes in plasma micronutrient status following dietary supplementation.  First World Congress on Men’s Health, Vienna, Austria, November 2001.

Wise JA, Rieter I, Prock P, Lawrence C, Bayer B, Kunze M, Rieder A, Hesslink RL, Mixed fruit and vegetable concentrates increase serum antioxidants associated with cardiovascular disease and cancer protection.  9th International Congress on Anti-Aging & Biomedical Technologies, Las Vegas, NV, December 2001.

Plotnick GD, Corretti MC, Vogel RA, Hesskink R Jr, Balon T, Wise JA.  The effects of supplemental phytonutrients on endothelial function.  2nd International Congress on Heart Disease-New Trends in Research, Diagnosis and Treatment, Washington DC, July 2001.

Calendar Year 2000

Publications

Wise JA, Voy RO. Nutritional supplements for sports: aids to exercise performance and recovery. Journal of American Nutraceutical Association, 3: 34-36, 2000.

Leeds AR, Ferris EA, Staley J, Ayesh R, Ross F. Availability of micronutrients from dried, encapsulated fruit and vegetable preparations: a study in healthy volunteers. Journal of Human Nutrition and Dietetics, 13: 21-27, 2000.

Wise, JA. Health benefits of fruits and vegetables: The protective role of phytonutrients. In: Vegetables, fruits and herbs in health promotion. (Ed.) Watson RR. CRC Press, NY, 2000.

Gallaher CM, Munion J, Hesslink Jr RL, Wise JA, Gallaher DD. Cholesterol reduction by glucomannan and chitosan is meditated by changes in cholesterol absorption and bile acid and fat excretion in rats.  Journal of Nutrition, 130: 2753-2759, 2000.

Presentations

Kraemer WJ, Volek JS, Gomez AL, Weyers A, Love DM, Davis CJ, Wise JA, Hesslink RL. Effect of a free living weight loss program on body composition and serum lipids in men and women. American College of Sports Medicine conference, Indianapolis, May 2000.

Volek JS, Gomez AL, Weyers A, Love DM, Davis CJ, Wise JA, Hesslink RL, Kraemer WJ. Comparison of body composition using body pod and DEXA before and after weight loss. American College of Sports Medicine conference, Indianapolis, May 2000.

Schmidt M, Askew EW, Roberts DE, Ensign Jr. W, Hesslink Jr R, Wise JA. Efficacy of a phytochemical antioxidant supplement on the reduction of exercise-induced oxidative stress. Experimental Biology, San Diego, April 2000.

Prior RL, Cao G, Hesslink Jr R, Wise J, Askew W, Ensign W, Roberts DE. Plasma and urine antioxidant capacity (AC) in men during physical training while consuming a dietary antioxidant supplement. Experimental Biology, San Diego, April 2000.

Ensign WY, Roberts DE, Reading JE, Askew EW, Hesslink RL, Wise JA, Schmidt M. Supplemental antioxidant effects on immune cells after a 24-day military training exercise. Experimental Biology, San Diego, April 2000.

Gallaher DD, Gallaher CM, Mahrt GJ, Carr TP, Hollingshead C, Askew EW, Hesslink Jr RL, Wise JA. Reduction in serum cholesterol by a chitosan and glucomannan supplement in humans. relationship to steroid excretion. Experimental Biology, San Diego, April 2000.

Mahrt G, Hollingshead C, Gallaher DD, Hesslink Jr RL, Wise JA. Effects of a glucomannan/chitosan supplement on metabolic rate, cholesterol and body composition. Experimental Biology conference, San Diego, April 2000.

Wise JA, The latest clinical research on whole food nutrition. Nutraceutical and Medicine Conference, American Nutraceutical Association, San Diego CA, March 2000.

Calendar Year 1999

Publications

Smith MJ, Inserra PF, Watson RR, Wise JA, O’Neill KL.  Supplementation with fruit and vegetable extracts may decrease DNA damage in the peripheral lymphocytes of an elderly population.  Nutrition Research, 19: 1507-1518, 1999.

Inserra PF, Jiang S, Solkoff DL, Lee J, Zhang Z, Xu M, Hesslink Jr. R, Wise JA, Watson RR.  Immune function in elderly smokers and nonsmokers improves during supplementation with fruit and vegetable extracts.  Integrative Medicine, 2: 3-10, 1999.

Presentations

Gallaher CM, Munion J, Hesslink Jr R, Wise JA, Gallaher DD. Glucomannan and chitosan lower cholesterol by reducing cholesterol absorption. Experimental Biology conference, Washington DC, April 1999.


Wise JA, Hesslink Jr RL, Watson RR, O'Neill KL. Supplementation with fruit and vegetable extracts improves immune status and other biomarkers of aging. Proceedings of the 7th International Conference on Anti-Aging Medicine and Bio Medical Technology, Las Vegas, 1999.

Wise JA. Supplementation with fruit and vegetable extracts reduces DNA damage in the peripheral lymphocytes of an elderly population. Nutraceuticals and Medicine Conference, San Diego, 1999.

Morin RJ. Changes in plasma carotenoid, alpha-tocopherol and lipid peroxide levels in response to supplementation with concentrated fruit and vegetable extracts. Nutraceuticals and Medicine Conference, San Diego, 1999.

Wise JA. Nutritional interventions which improve predictive biomarkers of aging and reduce the risk of chronic diseases. HealthTrends 2000, Copenhagen, Denmark, August 1999.

Calendar Year 1998

Publications

Kaats GR, Keith SC, Pullin D, Squires Jr. WG, Wise JA, Hesslink Jr. R, Morin RJ. Safety and efficacy evaluation of a fitness club weight loss program. Advances in Therapy, 15: 345-361, 1998.

Kaats GR, Wise JA, Morin R, Pullin D, Squires Jr. W, Hesslink Jr. R.  Positive effects of nutritional supplements on body composition biomarkers of aging during a weight loss program. Journal of American Nutraceutical Association, 1: 18-24, 1998.

Kaats GR, Wise JA, Morin R, Pullin D, Squires Jr. W, Murrieta TG, Hesslink Jr. R.  Reductions in DEXA measurements of body fat with different levels of involvement in a weight loss program using dietary supplements. Journal of American Nutraceutical Association, 1: 49-56, 1998.

Kaats GR, Keith SC, Croft HA, Pullin D, Squires Jr. W, Wise JA.  Dietary supplements and a behavior modification plan improve the safety and efficacy of pharmacotherapy. Advances in Therapy, 15: 167-179, 1998.

Presentations

Smith MJ, Inserra PF, Bowden D, Wise JA, Hesslink Jr. RL, Watson RR, O'Neill KL. Supplementation with fruit and vegetable extracts reduces DNA damage in the peripheral lymphocytes of an elderly population. 38th Annual Meeting of the American Society of Cell Biology, San Francisco, 1998.

Inserra PF, Jiang S, Solkoff D, Lee J, Zhen Z, Xu M, Wise JA, Hesslink Jr. RL, Watson RR. Immune function improves during fruit and vegetable extract supplementation. 38th Annual Meeting of the American Society of Cell Biology, San Francisco, 1998.

Wise JA, Leeds A, Ferris E, Hesslink Jr. RL.  Bioavailability of phytonutrients from mixed fruit and vegetable extracts in healthy volunteers. Experimental Biology conference, San Francisco, 1998.

Calendar Year 1997

Presentations

Kaats GR, Wise JA, Hesslink R, Pullin D, Squires W.  The fallacy of using scale weight (SW) and body mass index (BMI) to evaluate the efficacy and safety of nutritional ergogenic aids. Canadian Society of Exercise Physiology, Toronto, 1997.

Kaats GR, Wise JA, Morin R, Pullin D, Squires Jr. W, Hesslink Jr. RL.  Effects of using nutritional supplements and behavior modification on the biomarkers of aging. Proceedings of the 5th International Conference on Anti-Aging Medicine and Bio Medical Technology, Las Vegas, 1997.

Kaats GR, Wise JA.  The effects of nutritional supplements and behavior modification on serum cholesterol and self-reported well-being. Proceedings of the 5th International Conference on Anti-Aging Medicine and Bio Medical Technology, Las Vegas, 1997.

Additional Publications

Wise JA, Morin RJ, Sanderson R, Blum K.  Changes in plasma carotenoid, alpha-tocopherol, and lipid peroxide levels in response to supplementation with concentrated fruit and vegetable extracts: a pilot study. Current Therapeutic Research, 57: 445-458, 1996.

Kaats GR, Wise JA, Blum K, Morin RJ, Adelman JA, Craig J, Croft HA.  The short-term therapeutic efficacy of treating obesity with a plan of improved nutrition and moderate caloric restriction. Current Therapeutic Research, 51: 261-274, 1992.

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